Consortium analysis of 7 candidate SNPs for ovarian cancer

SJ Ramus; RA Vierkant; SE Johnatty; MC Pike; DJ Van Den Berg; AH Wu; CL Pearce; U Menon; A Gentry-Maharaj; SA Gayther; RA DiCioccio; V McGuire; AS Whittemore; H Song; DF Easton; PDP Pharoah; M Garcia-Closas; S Chanock; J Lissowska; L Brinton; KL Terry; DW Cramer; SS Tworoger; SE Hankinson; A Berchuck; PG Moorman; JM Schildkraut; JM Cunningham; M Liebow; SK Kjaer; E Hogdall; C Hogdall; J Blaakaer; RB Ness; KB Moysich; RP Edwards; ME Carney; G Lurie; MT Goodman; S Wang-Gohrke; S Kropp; J Chang-Claude; PM Webb; X Chen; J Beesley; G Chenevix-Trench; EL Goode; D Bowtell; A Green; A DeFazio; D Gertig; N Traficante; S Moore; J Hung; S Fereday; K Harrap; T Sadkowsky; A Mellon; R Robertson; T Vanden Bergh; J Maidens; K Nattress; YE Chiew; A Stenlake; H Sullivan; B Alexander; P Ashover; S Brown; T Corrish; L Green; L Jackman; K Martin; B Ranieri; J White; V Jayde; VL Bowes; P Mamers; T Schmidt; H Shirley; S Viduka; H Tran; S Bilic; L Glavinas; A Proietto; S Braye; G Otton; T Bonaventura; J Stewart; M Friedlander; D Bell; S Baron-Hay; A Ferrier; G Gard; D Nevell; B Young; C Camaris; R Crouch; L Edwards; N Hacker; D Marsden

Journal article

Consortium analysis of 7 candidate SNPs for ovarian cancer

SJ Ramus, RA Vierkant, SE Johnatty, MC Pike, DJ Van Den Berg, AH Wu, CL Pearce, U Menon, A Gentry-Maharaj, SA Gayther, RA DiCioccio, V McGuire, AS Whittemore, H Song, DF Easton, PDP Pharoah, M Garcia-Closas, S Chanock, J Lissowska, L Brinton Show all

International Journal of Cancer | Published : 2008

DOI: 10.1002/ijc.23448

Abstract

The Ovarian Cancer Association Consortium selected 7 candidate single nucleotide polymorphisms (SNPs), for which there is evidence from previous studies of an association with variation in ovarian cancer or breast cancer risks. The SNPs selected for analysis were F31I (rs2273535) in AURKA, N372H (rs144848) in BRCA2, rs2854344 in intron 17 of RB1, rs2811712 5′ flanking CDKN2A, rs523349 in the 3′ UTR of SRD5A2, D302H (rs1045485) in CASP8 and L10P (rs1982073) in TGFB1. Fourteen studies genotyped 4,624 invasive epithelial ovarian cancer cases and 8,113 controls of white non-Hispanic origin. A marginally significant association was found for RB1 when all studies were included [ordinal odds ratio ..

View full abstract